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245 Associations between patient acceptable symptom stateand three domains of the disease in SLE: a cross-sectional study of 1,364 patients from the spanish society of rheumatology lupus registry

Tomas R Vazquez Rodriguez, Iñigo Rua Figueroa, Victor Del Campo Perez, Javier Narváez-García, Francisco Javier López-Longo, Maria Galindo Izquierdo, Jaime Calvo Alen, Antonio Fernandez Nebro, Juan Ovalles-Bonilla, Paula Rubio Muñoz, Eva Tomero Muriel, Coral Mouriño Rodriguez (+8 others)
2019 Abstracts   unpublished

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region-binding site of miR-19a. In the control group, we identified polymorphism rs3093665 in only 1 control. We observed an association between polymorphism rs3093665 and organic brain syndrome (p=0.001), an association between polymorphism rs3093666 and thrombocytopenia (p=0.02) and an association between polymorphism rs3093667 and hematuria (p=0.024). Conclusions To our knowledge, this is the first study to evaluate polymorphisms in miRNA regions of TNFA gene in SLE. We identified
more » ... m rs3093665 and rs 3093667, both into miRNA region-binding sites. Alterations contribute to the development of pathological conditions and clinical disorders in SLE. Funding Source(s): CAPES CNPq FAPESP
doi:10.1136/lupus-2019-lsm.245 fatcat:u562zesclbakto7xha7c6q57ma
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Tomas R Vazquez Rodriguez, Iñigo Rua Figueroa, Victor Del Campo Perez, Javier Narváez-García, Francisco Javier López-Longo, Maria Galindo Izquierdo, Jaime Calvo Alen, Antonio Fernandez Nebro, Juan Ovalles-Bonilla, Paula Rubio Muñoz, Eva Tomero Muriel, Coral Mouriño Rodriguez, Esther Uriarte Isacelaya, Angela Pecondón Español, Mercedes Freire González, Ricardo Blanco Alonso, Marian Gantes Mora, Monica Ibañez Barcelo, Carlos Montilla Morales, Jose Maria Pego Reigosa. "245 Associations between patient acceptable symptom stateand three domains of the disease in SLE: a cross-sectional study of 1,364 patients from the spanish society of rheumatology lupus registry." Abstracts (2019)