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Constitutive expression and abnormal glycosylation of transferrin receptor in acute T-cell leukemia
1989
Cancer Research
The expression of transferrin receptors (TrfRs) was investigated in acute T-cell leukemia (T-ALL) blasts at the molecular, biochemical, immunological, and functional level. TrfRs, although not detected on quiescent T-cells from normal adults, are constitutively expressed at high level on the blasts from all T-ALL patients and bind normally to transferrin. Their number is modulated by the intracellular iron level, but is independent of exogenous interleukin 2. They also exhibit immunological and
pmid:2582441
fatcat:slslizpf7nhklbszbkws3kcq5e