SAT0567 The leading risk factors for developing intensive pain syndrome in the knee joints in patients with ostheoartritis

L.I. Alekseeva, E.A. Taskina, N.G. Kashevarova, S.G. Anikin, E.P. Sharapova, E.A. Strebkova, T.A. Korotkova, A.U. Feklistov
2018 Saturday, 16 JUNE 2018   unpublished
Conclusions: Our results showed that not macrophages but osteoclast infiltration in subchondral bone were associated with symptomatic knee OA. Osteoclasts release protons that generate a local acidosis, which might be a potent activator of nociceptors leading to increased pain signaling 4) . Increased osteoclast activity might be key features associated with bone pain in knee OA.
doi:10.1136/annrheumdis-2018-eular.4639 fatcat:p3ze3nkcvraeto7pvklo5ckgvi