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on behalf of the Ophthalmic Statistics Group DEFINING THE PROBLEM Investigating multiple research questions, or hypotheses, within one study is a common scenario in biomedical research with many examples in ophthalmology. As the number of statistical tests increases, the overall chance that we draw an erroneous conclusion in our study gets higher in a predictable manner. Each statistical test conducted at the conventional 5% significance level (α) has a one in 20 chance (or 0.05 probability) ofdoi:10.1136/bjophthalmol-2015-306784 pmid:26112870 fatcat:ftpt5rw5p5f7hcuvbzfmrrebuq