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Physical Review E
We present a simple physical model to estimate the blocked pore probability of an ion channel that can be blocked by a highly charged drug in solution. The model is inspired by recent experimental work on the blocking of the PA 63 channel, involved in the anthrax toxin infection, by a highly charged drug ͓Karginov et al. PNAS 102, 15075 ͑2005͔͒. The drug binding to the pore is highly specific but the strong dependence of blocking on the applied voltage and electrolyte concentration suggestsdoi:10.1103/physreve.73.041914 pmid:16711843 fatcat:5b5gjgautfectg5gju43tcehre