In this study, simultaneous aero-structural design was performed for HALE aircraft wing. The span and the shape of main spar were considered as design variables. To maximize aerodynamic performance and to minimize weight, multi-objective optimization was used. Nonlinear static aeroelastic analysis was performed to compute large deflection of wing. Design of experiment and response surface method were used to reduce computation cost in the design process. Also, aerodynamic performances of deformed wing and rigid wing were compared.