Hydroxyl dendrimers target reactive microglia in multiple neuroinflammatory models, including cerebral palsy. Insights on the differential uptake of dendrimers between subpopulations of microglia will enable the better design of precise nanomedicines to treat neuroinflammation. We have previously demonstrated that microglia of rabbits with cerebral palsy undergo change to a pro-inflammatory phenotype that selectively takes up dendrimer nanoparticles proportional to the severity of the injury. However, the functional