A Cohort of Patients with COVID-19 in a Major Teaching Hospital in Europe

Alberto Borobia, Antonio Carcas, Francisco Arnalich, Rodolfo Álvarez-Sala, Jaime Monserrat-Villatoro, Manuel Quintana, Juan Figueira, Rosario Torres Santos-Olmo, Julio García-Rodríguez, Alberto Martín-Vega, Antonio Buño, Elena Ramírez (+18 others)
2020 Journal of Clinical Medicine  
Since the confirmation of the first patient infected with SARS-CoV-2 in Spain in January 2020, the epidemic has grown rapidly, with the greatest impact on the region of Madrid. This article describes the first 2226 adult patients with COVID-19, consecutively admitted to La Paz University Hospital in Madrid. Methods: Our cohort included all patients consecutively hospitalized who had a final outcome (death or discharge) in a 1286-bed hospital of Madrid (Spain) from 25 February (first case
more » ... (first case admitted) to 19 April 2020. The data were manually entered into an electronic case report form, which was monitored prior to the analysis. Results: We consecutively included 2226 adult patients admitted to the hospital who either died (460) or were discharged (1766). The patients' median age was 61 years, and 51.8% were women. The most common comorbidity was arterial hypertension (41.3%), and the most common symptom on admission was fever (71.2%). The median time from disease onset to hospital admission was 6 days. The overall mortality was 20.7% and was higher in men (26.6% vs. 15.1%). Seventy-five patients with a final outcome were transferred to the intensive care unit (ICU) (3.4%). Most patients admitted to the ICU were men, and the median age was 64 years. Baseline laboratory values on admission were consistent with an impaired immune-inflammatory profile. Conclusions: We provide a description of the first large cohort of hospitalized patients with COVID-19 in Europe. Advanced age, male sex, the presence of comorbidities and abnormal laboratory values were more common among the patients with fatal outcomes.
doi:10.3390/jcm9061733 pmid:32512688 fatcat:bzwoaqhbqveqbhocpy6zh3u7za