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Journal of Clinical Medicine STATE OF THE ART 55 Maedica A Journal of Clinical Medicine
The idiopathic nephrotic syndrome is a common chronic kidney diseases in children defined by the association of massive proteinuria and hypoalbuminemia in a relapsing/remission course, with histological aspect of minimal changes (also called minimal change disease) in the majority of the cases, but its pathogenesis remains not very well known. Clinical and immunological studies have consistently shown a relationship between atopic diathesis, immunoglobulin E and cytokines involved infatcat:354vaiwe3vddvnh7l5hatoi4gy