Formulation, Characterization and Evaluation of Gastro-Retentive Floating Tablets of Norfloxacin
INTRODUCTION The most promising and safest route of drug delivery is the oral route and is considered as the most promising route of drug delivery. Effective oral drug delivery depends upon the factors such as bowel emptying, transit time of dosage form through the Digestive tract, therapeutic delivery from the dosage form etc. These factors affect the humans in variable ways. The factors such as neutralization by acid or delayed absorption may also lead to precipitate formation of may cause
... ion of may cause neutralization of drug leading to non-uniform absorption and makes the bioavailability unpredictable. Controlled-release drug delivery systems (CRDDS) provide drug release at a predetermined, predictable, and monitored rate. Hence a beneficial delivery system should possesses the ability to control and prolong the gastric emptying time and can deliver drugs in higher concentrations to the absorption site (i.e. Upper part of the small intestine)      . Such gastro retentive systems remain in the gastric region for several hours and hence significantly prolong the gastric residence time of drugs [6, 7] . Thus the prolonged retention enhances bioavailability, reducing the wastage of drug improving solubility for drug. All the above requirements are met by the floating drug delivery systems and hence effective delivery of drugs occurs to the absorption window for the treatment of gastric disorders such as gastro-esophageal reflux etc      . Norfloxacin is a fluoroquinolones, broad spectrum antibiotic, and is used in the treatment of urinary tract infections, prostatitis and gonorrhea. Norfloxacin is least absorbed from the lower part of the gastrointestinal tract and is better absorbed from the stomach. This drug has a repetitive dose schedule (400 mg twice daily), short biological half-life (3-4 h) and reduced bioavailability (30-40%). Thus, Norfloxacin is a candidate for the development of a gastro-retentive drug delivery system. In this work, the details of formulation development and evaluation of floating tablets of Norfloxacin is described. ABSTRACT The purpose of the research work was to develop gastro-retentive drug delivery system of Norfloxacin. Floating tablets were prepared by wet granulation method using sodium bicarbonate and citric acid anhydrous, like Hydroxypropyl Methylcellulose (HPMC K100M), Xanthum gum, and Microcrystalline Cellulose (MCC). Norfloxacin floating tablets prepared were found to be good without chipping, capping and sticking. The drug content was found to be uniform in all the tablet formulations. Formulation F3 and F5 showed desired drug release and thus selected as the best formulation. Finally optimized formulation F3 and F5 complying with all properties of floating tablets were found to be satisfactory in all aspects.