Role of the Central Amygdala in Modulating the Pituitary-Adrenocortical and Clinical Responses in Experimental Herpes Simplex Virus-1 Encephalitis

Joseph Weidenfeld, Anna Itzik, Irit Goshen, Raz Yirmiya, Tamir Ben-Hur
2005 Neuroendocrinology  
tor hyperactivity and aggressive behavior. These responses were also attenuated in rats with cAMG lesions. The cAMG plays an important role in mediating the neuroendocrine, febrile and behavioral responses to HSV-1 infection. Abstract The amygdala is known to regulate neuroendocrine and behavioral responses to a variety of stimuli. Herpes simplex virus-1 (HSV-1) is the common cause of viral encephalitis, manifested by hypothalamic-pituitary-adrenal (HPA) axis activation, fever, hypermotor
more » ... ty and aggression. We examined here the role of the central amygdala (cAMG) in regulating the HPA axis function, febrile and behavioral responses to HSV-1 infection in rats. Bilateral electrolytic lesions were performed in the cAMG. HSV-1 encephalitis was induced by intracerebroventricular (ICV) inoculation of purifi ed virions. Motor activity and body temperature were examined by a biotelemetric system. ICV inoculation of HSV-1 caused a marked time-dependent increase in serum corticotropin (ACTH) and corticosterone at 4 and 24 h post-infection. These responses were attenuated in rats with bilateral lesions of the cAMG. HSV-1 infection induced fever, mo-
doi:10.1159/000087924 pmid:16131813 fatcat:ghwqucmkwzdi3gnomezzpdiwge