Polymorphism of Homopolymeric Glutamines in Coactivators for Nuclear Hormone Receptors

YOSHITAKA HAYASHI, MARIKO YAMAMOTO, SACHIKO OHMORI, TOYONE KIKUMORI, TSUNEO IMAI, HIROOMI FUNAHASHI, HISAO SEO
1999 Endocrine journal  
Some of the recently identified coactivators which interact with members of nuclear hormone receptors contain a stretch of homopolymeric glutamines (poly-Q). Length of poly-Q in several genes are known to be polymorphic in healthy subjects, and extraordinary expansion of poly-Q in specific genes is known to cause neurodegenerative disorders. In the present study, we investigated whether such polymorphism can be observed in two Coactivators, CBP (CREB [cyclic AMP responsive element binding
more » ... ement binding protein]-binding protein) and AIB 1 /ACTR
doi:10.1507/endocrj.46.279 pmid:10460012 fatcat:iyhj56tnwbbrlh2kl3a7jagfre