DEVELOPMENT AND VALIDATION OF UV SPECTROSCOPIC METHOD FOR THE DETERMINATION OF LINAGLIPTIN AND METFORMIN HYDROCHLORIDE IN BULK AND TABLET DOSAGE FORM

M Reddy, Boga Bhavana, M Sandhya
2018 J. Global Trends Pharm Sci   unpublished
Key Words Linagliptin, Metformin, Absorbance ratio, Quantitative analysis, LOD, LOQ. A simple, economic, sensitive, precise and accurate UV spectrophotometric method was developed and validated for quantification of Linagliptin (LNG) and Metformin hydrochloride (MET) in bulk and in tablet dosage form. Adequate drug solubility and maximum assay sensitivity was found in water at 273nm and 233nm respectively. Calibration graph constructed at 273nm and 233nm was linear in concentration range of
more » ... ration range of 2-10μg/ml with correlation coefficient of 0.998 and 0.999 respectively. The method was validated as per ICH guidelines in terms of linearity (within 2-10µg/ml), accuracy (% recovery), precision, specificity and robustness
fatcat:rpvebuk2x5ag3d5xzv5z2avrqq