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Analyzing GPCR-Ligand Interactions with the Fragment Molecular Orbital (FMO) Method
G-protein-coupled receptors (GPCRs) have enormous physiological and biomedical importance, and therefore it is not surprising that they are the targets of many prescribed drugs. Further progress in GPCR drug discovery is highly dependent on the availability of protein structural information. However, the ability of X-ray crystallography to guide the drug discovery process for GPCR targets is limited by the availability of accurate tools to explore receptor-ligand interactions. Visual inspectiondoi:10.1007/978-1-0716-0282-9_11 pmid:32016893 fatcat:tmnjrtcsqnejvhh7lyq6aqmliy