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Asbestos induces mitochondrial DNA damage and dysfunction linked to the development of apoptosis
2003
American Journal of Physiology - Lung cellular and Molecular Physiology
nett Van Houten, and Brooke T. Mossman. Asbestos induces mitochondrial DNA damage and dysfunction linked to the development of apoptosis. To test the hypothesis that asbestos-mediated cell injury is mediated through an oxidant-dependent mitochondrial pathway, isolated mesothelial cells were examined for mitochondrial DNA damage as determined by quantitative PCR. Mitochondrial DNA damage occurred at fourfold lower concentrations of crocidolite asbestos compared with concentrations required for
doi:10.1152/ajplung.00038.2003
pmid:12909582
fatcat:pvcivnbwa5cjxpcrwo5eizhkxy