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The PVDF flat-membrane was modified by hydrophilic nano-TiO2, which blending by ultrasonication and mechanical stirring pretreatment in phase inversion method. To evaluate the permeate productivity and anti-fouling capacity of protein solution, both the critical flux (JCW) and threshold flux (JTH) of PVDF and PVDF-TiO2 membrane were firstly measured by Advanced Constant Pressure-step Method in cross-flow filtration apparatus. Some evaluation indicators were utilized to analyze the results, suchdoi:10.1051/e3sconf/202014401015 fatcat:6dmquzwagrckvkj2yjfqnsbb4u