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Prenatal androgen treatment does not alter the firing activity of hypothalamic arcuate kisspeptin neurons in female mice
[article]
2021
bioRxiv
pre-print
Neuroendocrine control of reproduction is disrupted in many individuals with polycystic ovary syndrome, who present with increased luteinizing hormone (LH), and presumably gonadotropin-releasing hormone (GnRH), release frequency, and high androgen levels. Prenatal androgenization (PNA) recapitulates these phenotypes in primates and rodents. Female offspring of mice injected with dihydrotestosterone (DHT) on gestational D16-18 exhibit disrupted estrous cyclicity, increased LH and testosterone,
doi:10.1101/2021.07.19.452845
fatcat:xhr67sltobgy7gjyomdqpyg4aq