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TFregulomeR reveals transcription factors' context-specific features and functions
2019
Nucleic Acids Research
Transcription factors (TFs) are sequence-specific DNA binding proteins, fine-tuning spatiotemporal gene expression. Since genomic occupancy of a TF is highly dynamic, it is crucial to study TF binding sites (TFBSs) in a cell-specific context. To date, thousands of ChIP-seq datasets have portrayed the genomic binding landscapes of numerous TFs in different cell types. Although these datasets can be browsed via several platforms, tools that can operate on that data flow are still lacking. Here,
doi:10.1093/nar/gkz1088
pmid:31754708
pmcid:PMC6954419
fatcat:joehczq4srhv7gy2hvvqdw4uma