Abbreviations: HSIL, high grade squamous intraepithelial lesions; LLETZ, large loop excision of the transformation zone; ASC, ambulatory surgery center Abstract Most of the cervical high grade lesions are now treated in the outpatient setting. Generally, the procedure is considered to have low surgical morbidity however, little is known about perioperative infection rates following this procedure. In order to reduce postsurgical risk of infection and patient discomfort, and to minimize the post

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... infection complication or scarring of the cervix, application of chlorhexidine vaginal suppositories with hyaluronic acid after cervical surgical treatment has been evaluated. The low rate (1.4%) of post-surgical infection in this series is due to the application of chlorhexidine vaginal suppositories after cervical surgical treatment in an Ambulatory Surgery Center qualified infection-prevention procedures. Noteworthy, the satisfactory colposcopy with the definition of the entire squamo columnar junction at the first follow-up demonstrates that preventing infection may aid to achieve an optimal tissue repair with a consequent satisfactory postsurgical diagnostic procedure. In our experience, the chlorhexidine 0.2% vaginal suppositories regimen displays no reported harms, scarce bacterial resistance, and good patient compliance and permits to reduce the postsurgical infection minimizing the patient discomfort after preinvasive cervical cancer treatment.