Effect of Isoliquiritin on Wound Healing in Scalded Rats

Qiang Tang, Qianli Tang
2020 Pakistan Journal of Zoology  
The aim of study was to investigate effect and possible mechanism of isoliquiritin on wound healing in scalded rats. The results show that at 24 h after the last administration, wound healing rate of isoliquiritin group was higher than that of model group (p=0.024). Compared with control group, thickness of epidermis and dermis in model group was thinner (p<0.001), and width of subdermal collagen fibers also decreased (p<0.001), inflammatory factors TNF-α, IL-6 and IL-1β in skin tissue
more » ... kin tissue increased (all p<0.001), and expression levels of Ang-1 and Tie-2 proteins in skin tissue decreased (both p<0.001). Compared with model group, thickness of epidermis, dermis and collagen fibers, and expression levels of Ang-1 and Tie-2 proteins in skin tissue in isoliquiritin group increased (all p<0.001), and inflammatory factors TNF-α, IL-6 and IL-1β contents and expression level of Ang-2 protein in skin tissue decreased (all p<0.001). Hence, this can be concluded that isoliquiritin can promote the healing of acute wounds in rats. The mechanism may be related to increasing skin thickness, inhibiting the release of inflammatory factors, up-regulating the expression of Ang-1 and Tie-2 proteins and down-regulating the expression of Ang-2 protein.
doi:10.17582/journal.pjz/20191010041047 fatcat:auhc463c2ffzfl2tppnokn5moe