Linking RNA Processing and Function

Run-Wen Yao, Chu-Xiao Liu, Ling-Ling Chen
<span title="2020-02-04">2020</span> <i title="Cold Spring Harbor Laboratory"> <a target="_blank" rel="noopener" href="" style="color: black;">Cold Spring Harbor Symposia on Quantitative Biology</a> </i> &nbsp;
RNA processing is critical for eukaryotic mRNA maturation and function. It appears there is no exception for other types of RNAs. Long noncoding RNAs (lncRNAs) represent a subclass of noncoding RNAs, have sizes of >200 nucleotides (nt), and participate in various aspects of gene regulation. Although many lncRNAs are capped, polyadenylated, and spliced just like mRNAs, others are derived from primary transcripts of RNA polymerase II and stabilized by forming circular structures or by ending with
more &raquo; ... small nucleolar RNA-protein complexes. Here we summarize the recent progress in linking the processing and function of these unconventionally processed lncRNAs; we also discuss how directional RNA movement is achieved using the radial flux movement of nascent precursor ribosomal RNA (pre-rRNA) in the human nucleolus as an example.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="">doi:10.1101/sqb.2019.84.039495</a> <a target="_blank" rel="external noopener" href="">pmid:32019863</a> <a target="_blank" rel="external noopener" href="">fatcat:xa6ehrm6kvhqfik6eawblsb6xy</a> </span>
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