Objectives: The study evaluated the effects of dentifrice with the proper amount of ginkgo biloba extract in the prevention of gum disease through clinical trials. Methods: Total sixty volunteers from the experimental group using experimental dentifrice (30 volunteers) and the control group using control dentifrice (30 volunteers) should use the experimental and control dentifrice for 8 weeks. Before the experiment, and 1, 2, 4, 6, and 8 weeks after the experiment, the papillary marginal

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... d gingival Index (the PMA index), Talbott's gingival index, patient hygiene performance index (PHP index), and Tureski's dental plaque index test were tested six times. Results: As a result of the PMA index measurement, the experimental and control groups showed statistically significant differences after 6 weeks, and the experimental group showed a significant decrease in the PMA index from 4 weeks after the experiment. The patient hygiene performance index measurement results showed a statistically significant difference between the experimental group and the control group after 4 weeks, and the experimental group showed a significant decrease in the PHP index 2 weeks after the experiment. Conclusions: The use of ginkgo-leaf-extract-containing-dentifrice confirmed that improved dental plaque removal, gingivitis relief, and periodontal disease prevention could be expected.