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Polymorphisms in Four Genes Related to Triglyceride and HDL-cholesterol Levels in the General Japanese Population in 2000

Hidenori Arai, Akira Yamamoto, Yuji Matsuzawa, Yasushi Saito, Nobuhiro Yamada, Shinichi Oikawa, Hiroshi Mabuchi, Tamio Teramoto, Jun Sasaki, Noriaki Nakaya, Hiroshige Itakura, Yuichi Ishikawa (+6 others)
2005 Journal of atherosclerosis and thrombosis  

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We studied the association of six common polymorphisms of four genes related to lipid metabolism with serum lipid levels. We selected single-nucleotide polymorphisms (SNPs) in the genes for cholesteryl ester transfer protein (CETP), lipoprotein lipase (LPL), hepatic lipase (LIPC), and apolipoprotein CIII (APOC3), and studied 2267 individuals randomly selected from the participants of Serum Lipid Survey 2000. There was a significant association of CETP polymorphism (D442G, Int14 +1 G → → → → →
more » ... and TaqIB), LPL polymorphism (S447X), and LIPC polymorphism (-514 → → → → → CT) with HDLcholesterol levels. We also found a significant association of LPL polymorphism (S447X) and APOC3 polymorphism (SstI) with triglyceride levels. This is the largest database showing the association of common genetic variants in lipid metabolism with serum lipid levels in the general Japanese population. Further study is necessary to elucidate the role of these gene polymorphisms in cardiovascular events. J Atheroscler Thromb, 2005; 12: 240-250.
doi:10.5551/jat.12.240 pmid:16205020 fatcat:e5x7plxyizfn3bfnq4et45gi5a
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Hidenori Arai, Akira Yamamoto, Yuji Matsuzawa, Yasushi Saito, Nobuhiro Yamada, Shinichi Oikawa, Hiroshi Mabuchi, Tamio Teramoto, Jun Sasaki, Noriaki Nakaya, Hiroshige Itakura, Yuichi Ishikawa, Yasuyoshi Ouchi, Hiroshi Horibe, Tohru Egashira, Hiroaki Hattori, Nobuo Shirahashi, Toru Kita. "Polymorphisms in Four Genes Related to Triglyceride and HDL-cholesterol Levels in the General Japanese Population in 2000." Journal of atherosclerosis and thrombosis 12.5 (2005) 240-250