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Centrosome cohesion is regulated by a balance of kinase and phosphatase activities
Journal of Cell Science
Centrosome cohesion and separation are regulated throughout the cell cycle, but the underlying mechanisms are not well understood. Since overexpression of a protein kinase, Nek2, is able to trigger centrosome splitting (the separation of parental centrioles), we have surveyed a panel of centrosome-associated kinases for their ability to induce a similar phenotype. Cdk2, in association with either cyclin A or E, was as effective as Nek2, but several other kinases tested did not significantlypmid:11707526 fatcat:hlkaxobrgneidahthuo46kff6q