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The persistence of intractable neurological disorders necessitates novel therapeutic solutions. We demonstrate the utility of direct in situ electrophoretic drug delivery to treat neurological disorders. We present a neural probe incorporating a microfluidic ion pump (FIP) for on-demand drug delivery and electrodes for recording local neural activity. The FIP works by electrophoretically pumping ions across an ion exchange membrane and thereby delivers only the drug of interest and not thedoi:10.1126/sciadv.aau1291 pmid:30167463 fatcat:rtrgqgj2qfc5rc34eolocxyt7u