Effect of Aegle marmelos (L.) Correa on alloxan induced early stage diabetic nephropathy in rats

Rajbir Bhatti, Shikha Sharma, Jatinder Singh, Amarjit Singh, M P S Ishar
2013 Indian journal of experimental biology  
Diabetic nephropathy (DN) has a complex pathogenesis and poor prognosis due to the lack of therapeutic interventions. The present study investigates the effect of A. marmelos leaf extract (AME) on early alloxan induced DN. The treatment with AME was found to significantly decrease the fasting blood sugar, total cholesterol, blood urea, creatinine and renal TBARS and increased the levels of renal reduced glutathione and catalase significantly as compared to the diabetic control group. The
more » ... l group. The maximum dose-dependent protection was observed at a dose of 200 mg kg(-1). Histological examination revealed marked reversal of the morphological derangements with AME treatment as indicated by a decrease in glomerular expansion, tubular dilatation and inflammatory cells. The present results conclude that AME treatment has a significant ameliorative effect on early changes induced in the kidneys by alloxan and improves the outcome of DN.
pmid:23926695 fatcat:phdpnl4ufnfhbbstioqpb7gju4