Fistula in Ano(Bhagandar) is most common and notorious disease among all anorectal dis-order and is prevalent in the populations worldwide and is second highest af-ter Arsha (hemorrhoids). Kshara Sutra (K.S.) is one of the chief modalities in the treatment of Bhagandara in Ayurvedic science. It produces inconveniences in routine life. It causes discomfort and pain that creates problem in day to day activities. Ksharsutra has been proved as a big revolution in the treatment of fistula in ano. To

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... find out an effective alternative to Apamarga ksharasutra in view of easy processing taken papaya kshir sutra opted for this clinical study. Sushruta the father of ancient Indian sur-gery has paid great attention towards bhagandar and dealt it systemically. Material and Methods:30 cases of Fistula in Ano of either sex were selected from the OPD and IPD of the CARIDD Hospital Kolkata.They were subjected for ligation of papaya kshirasutra in the Operation Theatre of CARIDD,Kolkata for the study. Observation & Result : UCT have been detected as mentioned in the fol-lowing mentioned principle and found to be equally (slightly less as compared to as it is mentioned in the standard Apamarga ksharasutra therapy. Discussion Burning pain is less observed during the treatment of Papaya kshirasutra therapy. UCT is also equally observed which is slightly less than the standard Snuhi apamarga ksharasutra (Standard) therapy.