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Laminin Modulates Morphogenic Properties of the Collagen XVIII Endostatin Domain
2002
Journal of Biological Chemistry
We have shown previously that the oligomeric endostatin domain of collagen XVIII (NC1) functioned as a motility-inducing factor regulating the extracellular matrix-dependent morphogenesis of endothelial cells. This motogenic activity gave rise to structures resembling filipodia and lamellipodia and was dependent on Rac, Cdc42, and mitogen-activated protein kinase. Here, we demonstrate that these properties of endostatin are primarily mediated by laminin in the basement membrane and heparan
doi:10.1074/jbc.m206358200
pmid:12237301
fatcat:ves3nu6cb5cqxdr7ls7zc4rcmy