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Multisubject statistical analyses of diffusion tensor images in regions of specific white matter tracts have commonly measured only the mean value of a scalar invariant such as the fractional anisotropy (FA), ignoring the spatial variation of FA along the length of fiber tracts. We propose to instead perform tract-based morphometry (TBM), or the statistical analysis of diffusion MRI data in an anatomical tract-based coordinate system. We present a method for automatic generation of white matterdoi:10.1007/978-3-540-75759-7_20 dblp:conf/miccai/ODonnellWG07 fatcat:m3zb7uj4lnbshik3vlqojxlbjm