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Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring
Local translation is rapidly regulated by extrinsic signals during neural wiring but its control mechanisms remain elusive. Here, we show that the extracellular cue Sema3A induces an initial burst in local translation that precisely controls the phosphorylation of the translation initiation factor eIF2α via the Unfolded Protein Response (UPR) kinase, PERK. Strikingly, in contrast to canonical UPR signaling, the Sema3A-induced eIF2α phosphorylation bypasses global translational repression anddoi:10.17863/cam.34307 fatcat:sgpjjem3nnfkvpciqdxk3mw6r4