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The Prion Protein Modulates A-type K+Currents Mediated by Kv4.2 Complexes through Dipeptidyl Aminopeptidase-like Protein 6
2013
Journal of Biological Chemistry
Prion protein (PrP) interacts with dipeptidyl aminopeptidase-like protein 6 (DPP6), but the functional significance was unknown. Results: PrP formed complexes with and impacted the function of potassium channels containing DPP6 and Kv4.2. Conclusion: PrP modulates voltage-dependent and kinetic properties of Kv4.2 channels. Significance: This could explain a phenotype of PrP knock-out mice and the effects of amyloid  oligomers. Widely expressed in the adult central nervous system, the cellular
doi:10.1074/jbc.m113.488650
pmid:24225951
pmcid:PMC3873577
fatcat:kndrklnq7rdrrfwwbrepcgtu4m