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Radionuclide diagnosis and therapy of neural crest tumors using iodine-131 metaiodobenzylguanidine
Journal of Nuclear Medicine
The successful application of [131I]metaiodobenzylguanidine (MIBG) in diagnosis and therapy of pheochromocytoma has led to its use in other tumors which derive from the neural crest and potentially concentrate this radiopharmaceutical as well. In the present series, MIBG total-body scintigraphy was used for detection of neuroblastoma in 47 patients and 47 cases of other neural crest tumors. The method was found to be as reliable in neuroblastoma (sensitivity 95%, specificity 100%), as itpmid:3102701 fatcat:webyjoskobberefwkt7dq3pkqq