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A simple, Accurate, precise technique was produced for the simultaneous estimation of the estimation of the Glecaprevir & Pibrentasvir in Pharmaceutical dosage form. Chromatogram was run through Kromosil C18 250x4.6mm,5m. MP containing Buffer 0.01N KH2PO4: ACN taken in the ratio 55:45 was pumped through column at a stream rate of 1ml/min. Buffer utilized in this technique was 0.1% Ortho phosphoric acid buffer. Temperature was maintained at 30°C. Improved wavelength chose was 260 nm. Retentiondoi:10.5281/zenodo.3270796 fatcat:zo7ocerqtfa2nnebc4t7kdqkcy