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Akt1 signaling coordinates BMP signaling and -catenin activity to regulate second heart field progenitor development
Second heart field (SHF) progenitors exhibit continued proliferation and delayed differentiation, which are modulated by FGF4/8/10, BMP and canonical Wnt/β-catenin signaling. PTEN-Akt signaling regulates the stem cell/progenitor cell homeostasis in several systems, such as hematopoietic stem cells, intestinal stem cells and neural progenitor cells. To address whether PTEN-Akt signaling is involved in regulating cardiac progenitors, we deleted Pten in SHF progenitors. Deletion of Pten caused SHFdoi:10.1242/dev.119016 pmid:25670795 fatcat:jvscloy3ezfzzic7djbfwl6b4a