Response of serum intact parathyroid hormone and milk calcium concentrations to vitamin D supplementation in breast-feeding mothers

A. J. Lucey, J. Y. Zhang, L. Carrabine, L. Nolan, J. R. Higgins, K. D. Cashman, M. Kiely
2011 Proceedings of the Nutrition Society  
Vitamin D status can influence serum intact parathyroid hormone (iPTH). While the Ca content of expressed breast milk (EBM) appears independent of maternal serum 25-hydroxyvitamin D (s25(OH)D) concentrations in mothers accustomed to both low (1) and high Ca (2) intakes, recent data in lactating PTH knockout mice suggest that iPTH may contribute to regulating milk Ca content and that this may be further influenced by maternal Ca intake (3) . Data on associations between circulating iPTH,
more » ... and milk Ca content are limited in human subjects. We investigated whether increasing maternal s25(OH)D concentrations altered circulating iPTH and the Ca content of EBM by means of a double-blind randomised placebo-controlled trial in 100 lactating women across three intervention groups that received 20 mg/d of vitamin D 3 (to achieve a total vitamin D intake of 25 mg/d),°500 mg Ca, or placebo over 12 weeks. Fasting serum iPTH and s25(OH)D were measured at baseline (BL) and endpoint (EP) using ELISA. Ca levels were quantified in EBM at four time points using atomic absorption spectrophotometry.
doi:10.1017/s0029665111001376 fatcat:c62cir65uverdgecin7czf6n6y