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Nerve Growth Factor Activates Persistent Rap1 Signaling in Endosomes
Journal of Neuroscience
We investigated a role for endogenous Rap1, a small monomeric GTP-binding protein of the Ras family, in nerve growth factor (NGF) signaling in PC12 cells. Although both epidermal growth factor (EGF) and NGF caused transient activation of Ras, only NGF induced the activation of Rap1. Moreover, Rap1 activation was sustained for hours, an effect that matched the sustained activation of the mitogen-activated protein kinase (MAPK) pathway. To investigate the molecular basis for Rap1 activation, wedoi:10.1523/jneurosci.21-15-05406.2001 pmid:11466412 fatcat:wdhnn7ynkrek3n4aflenc4gqk4