Efficacy of Pentoxifylline as an Antifibrotic Drug in Experimental Murine Schistosomal Hepatic Fibrosis

Eman A. Khalifa, Dalal M. Nemenqani
2014 Journal of the Egyptian Society of Parasitology  
Aim: The present study was a preliminary trial evaluating the possible antifibrotic effect of pentoxifylline on experimentally induced schistosomal hepatic fibrosis and, also, to investigate its effect on serum leptin and transforming growth factor -β1 levels as possible antifibrotic mechanisms in correlation with the hepatic fibrosis indices. Methods: In the study, ninety Swiss, laboratory bred parasite free, albino mice of both sexes were included. Ten mice served as a control non-infected,
more » ... rol non-infected, nontreated group and sacrificed at one time. The remaining 80 mice were infected subcutaneously with 50 Schistosoma mansoni cercariae/
doi:10.12816/0006486 fatcat:n43dkda6mjhahauaiqclswvohe