Androgens modulate the inflammatory response during acute wound healing

S. C. Gilliver
2006 Journal of Cell Science  
underlying the observed effects involve a direct, cellspecific upregulation of pro-inflammatory cytokine expression by macrophages, but not fibroblasts, in response to androgens. Androgens require the transforming growth factor ␤ ␤ signalling intermediate Smad3 to be present in order to influence repair and local pro-inflammatory cytokine levels. That reducing 5␣ ␣-dihydrotestosterone levels through 5␣ ␣-reductase antagonism markedly accelerates healing suggests a specific target for future
more » ... rget for future therapeutic intervention in impaired wound healing states in elderly males.
doi:10.1242/jcs.02786 pmid:16449322 fatcat:ugy2oybkhfhstdis46ov43lqwu