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Pairwise genetic interactions modulate lipid plasma levels and cellular uptake
[article]
2020
bioRxiv
pre-print
Genetic interactions (GIs), the joint impact of different genes or variants on a phenotype, are foundational to the genetic architecture of complex traits. However, identifying GIs through human genetics is challenging since it necessitates very large population sizes, while findings from model systems not always translate to humans. Here, we combined exome-sequencing and genotyping in the UK Biobank with combinatorial RNA-interference (coRNAi) screening to systematically test for pairwise GIs
doi:10.1101/2020.10.29.360818
fatcat:gsgqojgljzckhitcutvvzbvpnu