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Beh^et's disease (BD) is a chronic relapsing systemic vasculitis in which orogenital ulceration is a prominent feature. The disease affects manysystems and causes hypercoagulability. Wepresent a 27-year-old male patient who exhibited widespread great vessel thrombosis including right atrial and ventricular thrombi in the setting of rightsided infectious endocarditis and orogenital aphthous ulcerations and erythema nodosumdue to BD. Wereviewed the enigmatic prothrombotic state of BD, and discussdoi:10.2169/internalmedicine.40.68 fatcat:bcschdjd65dfxojmuk6vzhlvsq