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Design Space Construction of Multiple Dose-Strength Tablets Utilizing Bayesian Estimation Based on One Set of Design-of-Experiments
2012
Chemical and pharmaceutical bulletin
Design spaces for multiple dose strengths of tablets were constructed using a Bayesian estimation method with one set of design of experiments (DoE) of only the highest dose-strength tablet. The lubricant blending process for theophylline tablets with dose strengths of 100, 50, and 25 mg is used as a model manufacturing process in order to construct design spaces. The DoE was conducted using various Froude numbers (X 1 ) and blending times (X 2 ) for theophylline 100-mg tablet. The response
doi:10.1248/cpb.c12-00491
pmid:23124564
fatcat:cksbxbwvevho5h45i5aj3xf3ke