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SoftSearch: Integration of Multiple Sequence Features to Identify Breakpoints of Structural Variations
2013
PLoS ONE
Structural variation (SV) represents a significant, yet poorly understood contribution to an individual's genetic makeup. Advanced next-generation sequencing technologies are widely used to discover such variations, but there is no single detection tool that is considered a community standard. In an attempt to fulfil this need, we developed an algorithm, SoftSearch, for discovering structural variant breakpoints in Illumina paired-end nextgeneration sequencing data. SoftSearch combines multiple
doi:10.1371/journal.pone.0083356
pmid:24358278
pmcid:PMC3865185
fatcat:ifhtezbu25fvvac22zmmdrzzpq