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ROS Quenching Potential of the Epidermal Cornified Cell Envelope
2011
Journal of Investigative Dermatology
The cornified cell envelope (CE) is a specialized structure assembled beneath the plasma membrane of keratinocytes in the outermost layers of the epidermis. It is essential for the physical and permeability properties of the barrier function of the skin. Our skin is continuously exposed to atmospheric oxygen and threatened by reactive oxygen species (ROS). Here, we identify the CE as a first line of antioxidant defense and show that the small proline-rich (SPRR) family of CE precursor proteins
doi:10.1038/jid.2010.433
pmid:21248766
fatcat:6q2lmdy4b5anbnx4lfdnpojycq