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Improved accuracy of multiple ncRNA alignment by incorporating structural information into a MAFFT-based framework
2008
BMC Bioinformatics
Structural alignment of RNAs is becoming important, since the discovery of functional non-coding RNAs (ncRNAs). Recent studies, mainly based on various approximations of the Sankoff algorithm, have resulted in considerable improvement in the accuracy of pairwise structural alignment. In contrast, for the cases with more than two sequences, the practical merit of structural alignment remains unclear as compared to traditional sequence-based methods, although the importance of multiple structural
doi:10.1186/1471-2105-9-212
pmid:18439255
pmcid:PMC2387179
fatcat:ng7s44tylzbbdcwlhgx6j364z4