Transcriptional Coactivator Complexes

Anders M. Näär, Bryan D. Lemon, Robert Tjian
2001 Annual Review of Biochemistry  
The last two decades have witnessed a tremendous expansion in our knowledge of the mechanisms employed by eukaryotic cells to control gene activity. A critical insight to transcriptional control mechanisms was provided by the discovery of coactivators, a diverse array of cellular factors that connect sequence-specific DNA binding activators to the general transcriptional machinery, or that help activators and the transcriptional apparatus to navigate through the constraints of chromatin. A
more » ... f chromatin. A number of coactivators have been isolated as large multifunctional complexes, and biochemical, genetic, molecular, and cellular strategies have all contributed to uncovering many of their components, activities, and modes of action. Coactivator functions can be broadly divided into two classes: (a) adaptors that direct activator recruitment of the transcriptional apparatus, (b) chromatin-remodeling or -modifying enzymes.
doi:10.1146/annurev.biochem.70.1.475 pmid:11395415 fatcat:nrpswhgdrvbbxopt6xlsesja2i