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GERD, return of stomach contents into the esophagus, is one of the most common gastrointestinal disorders in medicine. Its common symptoms are heartburn and acid reflux. Usually, patients with GERD history develop clinical signs such as heartburn accompanied by functional constipation. Omeprazole, a proton pump inhibitor (PPIs), is a drug of choice for GERD but all patients do not respond to the drug and long-term use of these drugs leads to infections. According to the same physiopathologydoi:10.1016/j.jmhi.2015.11.002 fatcat:c2vkhxauhjhufaw5ys6e7i5krq