New Antibacterial Peptide Analogs of 5-Aminobenzimidazoles
새로운 펩티드 유사체인 5-aminobenzimidazoles의 합성

Humaira Y. Gondal, H. Mashooda, Muhammad Ali
2011 Journal of the Korean Chemical Society  
Three new peptide analogs 5a-c were obtained through coupling of 5-Amino benzimidazoles 2a-c with L-phenylalanine. For the purpose α-amino group was blocked with phthalic anhydride and activation of α-carboxy group of phenylalanine was carried out by preparing phthaloyl-L-phenylalanyl chloride 4. After developing a successful peptide linkage, the phthaloyl group was removed by treating 5a-c with hydrazine hydrate to get free peptides 6a-c, purified through a column of Amberlite (IR-4B). All of
more » ... hese compounds 2a-c and 5,6a-c have been characterized on the basis of their IR, 1 H NMR and EIMS analyses. Antibacterial activity of these compounds is also been reported.
doi:10.5012/jkcs.2011.55.4.650 fatcat:x6pd6qzut5h5jpsidifub6ftzq