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New Antibacterial Peptide Analogs of 5-Aminobenzimidazoles
새로운 펩티드 유사체인 5-aminobenzimidazoles의 합성
2011
Journal of the Korean Chemical Society
새로운 펩티드 유사체인 5-aminobenzimidazoles의 합성
Three new peptide analogs 5a-c were obtained through coupling of 5-Amino benzimidazoles 2a-c with L-phenylalanine. For the purpose α-amino group was blocked with phthalic anhydride and activation of α-carboxy group of phenylalanine was carried out by preparing phthaloyl-L-phenylalanyl chloride 4. After developing a successful peptide linkage, the phthaloyl group was removed by treating 5a-c with hydrazine hydrate to get free peptides 6a-c, purified through a column of Amberlite (IR-4B). All of
doi:10.5012/jkcs.2011.55.4.650
fatcat:x6pd6qzut5h5jpsidifub6ftzq