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Cellular uptake of the Antennapedia homeodomain polypeptide by macropinocytosis
2014
Biochemical and Biophysical Research Communications - BBRC
Antennapedia homeodomain has been shown to be able to translocate from extracellular space into the cytoplasm of cells in a receptor-independent manner. Its third a-helix domain, designated as "Penetratin", was proposed to be the functional transduction domain that is responsible for the translocation, and it is widely used for intracellular delivery of various exogenous proteins. Although Penetratin has been regarded to be the only element conferring the capacity on its parent polypeptide to
doi:10.1016/j.bbrc.2013.12.062
pmid:24361959
fatcat:mrvuya7toffvrpdvyj3zht6bi4