Photodynamic Therapy PDT PDT vascular endothelial growth factor VEGF PDT PDT 1 PDT KYSE70 5 3 2 PDT PDT PDT PDT . Abstract Photodynamic therapy (PDT) involves the administration of a photosensitizer followed by local illumination of a tumor with light of the appropriate wavelength to activate a specific drug Efficacy is high for small superficial tumors and except for temporary skin photosensitization there are no long-term side effects if appropriate protocols are followed However an inherent

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... onsequence of PDT is local hypoxia Hypoxia is the major stimulus for vascular endothelial growth factor (VEGF) production and secretion VEGF could contribute to tumor survival and regrowth and therefore could be one of the factors impairing PDT from achieving its full tumoricidal potential Therefore an understanding of tumor cell responses to PDT will help in the design of new interventions and potentially improve long-term survival of PDT treated patients It is well known that the cells in tumor tissue are heterogeneous in terms of morphology and differentiation status even if the tumor consists of progeny developed from a single neoplastic cell In this study we found that morphologically heterogeneous tumor cell clones had differing photosensitizer (talaporfin sodium) uptake and PDT 565 0871 2 1 A14 TEL: 06 6879 4735 FAX: 06 6879 7363