Factors contributing to variation in lipoprotein (a) in Melbourne Anglo-Celtic population

Z W Xiong, M L Wahlqvist, N T Wattanapenpaiboon, B M Biegler, N D H Balazs, D W Xiong, Y L Lim
2003 European Journal of Clinical Nutrition  
Aim: The purpose of this report is to survey the factors contributing to variation in lipoprotein(a) (Lp(a)) in a population-based sample of Anglo-Celtic Melburnians. Results: The plasma Lp(a) levels were highly skewed towards low levels in this population, with a median of 156 mg=l and a mean of 262 mg=l. Approximately 33% had plasma Lp(a) above the threshold value of 300 mg=l, while 35% had Lp(a) levels below 100 mg=l. The most commonly occurring phenotype was apo(a) S3. In this phenotype,
more » ... a) concentrations ranged from 10 to 596 mg=l. Lp(a) was consistently associated with diastolic blood pressure, systolic blood pressure, total protein, albumin and nitrogen excretion in the 40 -60 y age group. Multiple stepwise regression analyses, in non-dietary factors, were used to explain about 13% of the variance in Lp(a) (19% in men and 23% in women). Remarkably, in the <40 y age group, non-dietary factors may account for 86% of the variance in Lp(a) and dietary factors, analysed separately, 46%. Thus, although Lp(a) is mainly genetically determined, there are clearly other factors which contribute to variations in Lp(a) concentrations. Methods Subjects Recruitment was restricted to Australian-born persons of Anglo-Celtic background, namely Irish, Scottish, Welsh and English ancestry. Of the total number of recruits, 348 (157 males, 191 females) underwent Lp(a) measurement and apo(a) phenotype assessment. The mean age of the subjects was 56.07 AE 14.99 y (range 24 -86 y). The study protocol for
doi:10.1038/sj.ejcn.1601562 pmid:12627182 fatcat:e5373xeicvfjzaif5z7zdilliq